A Natural Choice For Your Hemophilia A Treatment

NUWIQ Closely Resembles Natural FVIII1,4-6

NUWIQ Does Not Contains Hamster Glycan Epitopes3

  • FVIII made from hamster cell lines may contain small amounts of animal proteins (also called glycan epitopes)4
  • The immune system may see glycan epitopes as foreign and produce antibodies (inhibitors) against it
Cell line comparisons

HEK = Human embryonic kidney; CHO = Chinese hamster ovary; BHK = Baby hamster kidney.

NUWIQ Has High Binding Affinity to von Willebrand Factor (VWF)2

  • VWF is another coagulation protein that’s important for helping the blood to clot2
  • In normal coagulation, FVIII and VWF bind and circulate together; VWF is like a chaperone for FVIII
  • This binding helps protect FVIII and keep it from being eliminated from the body too quickly2,4
  • Minimizing the amount of unbound FVIII in circulation may also help reduce the risk of inhibitor development2
NUWIQ Patient Brochure

Download your Guide to NUWIQ Patient Brochure

Read More
  1. Sandberg H, et al. Thromb Res.2012;130:808-817.
  2. Casademunt E, et al. Eur J Haematol. 2012;89:165-176.
  3. Kannicht C, et al. Thromb Res. 2013;131:78-88.
  4. Cafuir LA, Christine L. Kempton CL. Ther Adv Hematol. 2017;8(10):303–313.
  5. NUWIQ full Prescribing Information. Paramus, NJ: Octapharma; rev 2021.
  6. Lissitchkov T, Rusen L, Georgiev P, et al. Haemophilia. 2017;23:697-704.