NUWIQ Convenient and Flexible Dosing
NUWIQ offers physicians and nurses the convenience of flexible dosing for children and adults, and a wide range of dosage strength vials with the lowest, 2.5 ml diluent volume among currently approved FVIII products.
NUWIQ dosing for routine prophylaxis in children and adults1
| Patients | Dose (IU/kg) | Frequency of Infusions |
|---|---|---|
| Adolescents (12-17) and adults | 30-40 | Every other day |
| Children (2-11 years) | 30-50 | Every other day or 3 times per week |
NUWIQ dosing for on-demand treatment and control of bleeding in children and adults
| Type of Bleeding Episodes | Required Peak Post-Infusion factor VIII Activity (% of Normal or IU/dL) | Frequency of Dosing (hours) | Duration of Therapy (days) |
|---|---|---|---|
| Minor Superficial muscle or soft tissue and oral bleeds |
20-40 | 12-24 | At least 1 day, until the bleeding episode of resolved |
| Moderate to Major Hemorrhage into muscles, into oral cavity, hemarthrosis, known trauma |
30-60 | 12-24 | for 3-4 days or more until the bleeding episode is resolved |
| Life-Threatening Intracranial, intra-abdominal, gastrointestinal or intrathoracic bleeds, central nervous system bleeds, bleeding in retropharyngeal spaces or iliopsoas sheath, eyes, retina, fractures, or head trauma. |
60-100 | 8-24 | Until bleeding risk is resolved |
Dosing Flexibility with NUWIQ
- NUWIQ offers a broad range of dosage strengths with the lowest, 2.5 ml diluent volume among currently approved FVIII products.
- Available in 250 IU, 500 IU, 1000 IU, 1500 IU, 2000 IU, 2500 IU, 3000 IU, and 4000 IU vials
- Larger single-dose vials of 2500, 3000 and 4000 IU offer greater flexibility and convenience for patients requiring larger volumes of FVIII.
- All NUWIQ vial sizes are reconstituted with an easy-to-use 2.5 ml syringe, pre-filled with water for injection.
- Each NUWIQ box comes with a vial adapter, butterfly needle, and alcohol swabs in addition to the NUWIQ vial and pre-filled syringe.
Storing NUWIQ
- Keep NUWIQ in its original box in the refrigerator to protect it from exposure to light
- NUWIQ can be stored in the refrigerator for up to 24 months at 36-46°F (2-8°C)
- NUWIQ can be kept at room temperature (up to 77°F [25°C]) for a single period not exceeding 3 months
- After being stored at room temperature, NUWIQ must not be put back into the refrigerator
References
- NUWIQ full Prescribing Information. Paramus, NJ: Octapharma; rev 2021.