{"id":273,"date":"2018-08-31T01:04:59","date_gmt":"2018-08-31T01:04:59","guid":{"rendered":"https:\/\/nuwiq.wpengine.com\/hcp\/about-nuwiq\/molecular-design-implications\/"},"modified":"2025-01-09T17:37:28","modified_gmt":"2025-01-09T17:37:28","slug":"molecular-design-implications","status":"publish","type":"page","link":"https:\/\/nuwiqusa.com\/hcp\/about-nuwiq\/molecular-design-implications\/","title":{"rendered":"Molecular Design Implications"},"content":{"rendered":"\n<p>Unlike most of the currently available rFVIII products that are manufactured using a hamster cell line (Chinese Hamster Ovary or Baby Hamster Kidney cells), <a href=\"https:\/\/nuwiqusa.com\/hcp\/about-nuwiq\/human-cell-line\/\">NUWIQ is produced in a human cell line<\/a>.<sup>1,2<\/sup><\/p>\n<p>In fact, NUWIQ is the first and only rFVIII produced in a human cell line without chemical modification or protein fusion.<sup>1,2<\/sup><\/p>\n<h2>NUWIQ &ndash; Produced in a Human Cell Line<\/h2>\n<ul>\n<li>Human cell lines express only human post-translational modifications, like <a href=\"https:\/\/nuwiqusa.com\/hcp\/about-nuwiq\/human-cell-line\/\">glycosylation and sulfation<\/a>, to produce a rFVIII protein that closely resembles the FVIII the body produces naturally <sup>3<\/sup><\/li>\n<li>Protein expression in hamster cell lines results in glycosylation with non-human epitopes, which are potentially antigenic to humans<sup>3<\/sup><\/li>\n<li>NUWIQ contains only human glycan epitopes<\/li>\n<\/ul>\n\n","protected":false},"excerpt":{"rendered":"<p>Unlike most of the currently available rFVIII products that are manufactured using a hamster cell line (Chinese Hamster Ovary or&#8230;<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":422,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-273","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NUWIQ\u00ae Molecular Design | Human Cell Line rFVIII Production<\/title>\n<meta name=\"description\" content=\"NUWIQ\u00ae [Antihemophilic Factor (Recombinant)] is produced in a human cell line, containing only human glycan epitopes, without chemical modification. 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